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Gram Negative Bacteria Are Associated with the Early Stages of Necrotizing Enterocolitis

Overview of attention for article published in PLOS ONE, March 2011
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Title
Gram Negative Bacteria Are Associated with the Early Stages of Necrotizing Enterocolitis
Published in
PLOS ONE, March 2011
DOI 10.1371/journal.pone.0018084
Pubmed ID
Authors

Erica M. Carlisle, Valeriy Poroyko, Michael S. Caplan, John A. Alverdy, Donald Liu

Abstract

Necrotizing enterocolitis (NEC) affects 5-10% of infants born weighing less than 1500 g. Most models of NEC recapitulate late-stage disease with gut necrosis and elevated inflammatory mediators. Evaluation of NEC at earlier, less lethal stages of disease will allow investigation of initial disease triggers and may advance our understanding of temporal relationships between factors implicated in NEC pathogenesis. In this manuscript, we describe our investigation of early NEC and test the hypothesis that bacteria and inflammatory mediators differ between animals with early NEC and disease free animals.

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Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
Italy 2 3%
France 1 1%
Unknown 72 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 19%
Researcher 15 19%
Student > Master 12 16%
Student > Bachelor 6 8%
Student > Doctoral Student 6 8%
Other 10 13%
Unknown 13 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 27%
Medicine and Dentistry 20 26%
Immunology and Microbiology 6 8%
Biochemistry, Genetics and Molecular Biology 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 7 9%
Unknown 15 19%