| Title |
Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model
|
|---|---|
| Published in |
PLOS ONE, March 2011
|
| DOI | 10.1371/journal.pone.0017688 |
| Pubmed ID | |
| Authors |
Eriko Koshimizu, Shintaro Imamura, Jie Qi, Jamal Toure, Delgado M. Valdez, Christopher E. Carr, Jun-ichi Hanai, Shuji Kishi |
| Abstract |
Mutations that disrupt the conversion of prelamin A to mature lamin A cause the rare genetic disorder Hutchinson-Gilford progeria syndrome and a group of laminopathies. Our understanding of how A-type lamins function in vivo during early vertebrate development through aging remains limited, and would benefit from a suitable experimental model. The zebrafish has proven to be a tractable model organism for studying both development and aging at the molecular genetic level. Zebrafish show an array of senescence symptoms resembling those in humans, which can be targeted to specific aging pathways conserved in vertebrates. However, no zebrafish models bearing human premature senescence currently exist. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 1% |
| United States | 2 | 1% |
| Portugal | 1 | <1% |
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| Finland | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 132 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 35 | 25% |
| Student > Ph. D. Student | 29 | 21% |
| Student > Bachelor | 16 | 11% |
| Student > Master | 13 | 9% |
| Student > Doctoral Student | 6 | 4% |
| Other | 19 | 13% |
| Unknown | 23 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 48 | 34% |
| Biochemistry, Genetics and Molecular Biology | 40 | 28% |
| Medicine and Dentistry | 10 | 7% |
| Neuroscience | 5 | 4% |
| Engineering | 4 | 3% |
| Other | 8 | 6% |
| Unknown | 26 | 18% |