Title |
An Unexpected Role for the Clock Protein Timeless in Developmental Apoptosis
|
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Published in |
PLOS ONE, February 2011
|
DOI | 10.1371/journal.pone.0017157 |
Pubmed ID | |
Authors |
Linda P. O'Reilly, Simon C. Watkins, Thomas E. Smithgall |
Abstract |
Programmed cell death is critical not only in adult tissue homeostasis but for embryogenesis as well. One of the earliest steps in development, formation of the proamniotic cavity, involves coordinated apoptosis of embryonic cells. Recent work from our group demonstrated that c-Src protein-tyrosine kinase activity triggers differentiation of mouse embryonic stem (mES) cells to primitive ectoderm-like cells. In this report, we identified Timeless (Tim), the mammalian ortholog of a Drosophila circadian rhythm protein, as a binding partner and substrate for c-Src and probed its role in the differentiation of mES cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 2 | 4% |
Indonesia | 1 | 2% |
Portugal | 1 | 2% |
Brazil | 1 | 2% |
Sweden | 1 | 2% |
Unknown | 41 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 30% |
Researcher | 10 | 21% |
Student > Master | 7 | 15% |
Professor | 4 | 9% |
Professor > Associate Professor | 3 | 6% |
Other | 5 | 11% |
Unknown | 4 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 26 | 55% |
Biochemistry, Genetics and Molecular Biology | 7 | 15% |
Medicine and Dentistry | 3 | 6% |
Neuroscience | 3 | 6% |
Computer Science | 1 | 2% |
Other | 2 | 4% |
Unknown | 5 | 11% |