| Title |
Quantitative Proteomics Identifies the Myb-Binding Protein p160 as a Novel Target of the von Hippel-Lindau Tumor Suppressor
|
|---|---|
| Published in |
PLOS ONE, February 2011
|
| DOI | 10.1371/journal.pone.0016975 |
| Pubmed ID | |
| Authors |
Yanlai Lai, Mei Qiao, Meihua Song, Susan T. Weintraub, Yuzuru Shiio |
| Abstract |
The von Hippel-Lindau (VHL) tumor suppressor gene encodes a component of a ubiquitin ligase complex, which is best understood as a negative regulator of hypoxia inducible factor (HIF). VHL ubiquitinates and degrades the α subunits of HIF, and this is proposed to suppress tumorigenesis and tumor angiogenesis. However, several lines of evidence suggest that there are unidentified substrates or targets for VHL that play important roles in tumor suppression. |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 7% |
| France | 1 | 3% |
| Unknown | 26 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 24% |
| Student > Doctoral Student | 5 | 17% |
| Student > Ph. D. Student | 5 | 17% |
| Professor > Associate Professor | 3 | 10% |
| Student > Master | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 5 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 34% |
| Biochemistry, Genetics and Molecular Biology | 8 | 28% |
| Medicine and Dentistry | 2 | 7% |
| Business, Management and Accounting | 1 | 3% |
| Unspecified | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 5 | 17% |