| Title |
A Two-Gene Balance Regulates Salmonella Typhimurium Tolerance in the Nematode Caenorhabditis elegans
|
|---|---|
| Published in |
PLOS ONE, March 2011
|
| DOI | 10.1371/journal.pone.0016839 |
| Pubmed ID | |
| Authors |
Elizabeth K. Marsh, Maaike C. W. van den Berg, Robin C. May |
| Abstract |
Lysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought. |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 7% |
| France | 1 | 2% |
| Unknown | 42 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 26% |
| Student > Ph. D. Student | 8 | 17% |
| Student > Bachelor | 6 | 13% |
| Professor > Associate Professor | 3 | 7% |
| Student > Master | 3 | 7% |
| Other | 5 | 11% |
| Unknown | 9 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 46% |
| Biochemistry, Genetics and Molecular Biology | 6 | 13% |
| Immunology and Microbiology | 5 | 11% |
| Computer Science | 1 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 10 | 22% |