| Title |
Human Stiff-Person Syndrome IgG Induces Anxious Behavior in Rats
|
|---|---|
| Published in |
PLOS ONE, February 2011
|
| DOI | 10.1371/journal.pone.0016775 |
| Pubmed ID | |
| Authors |
Christian Geis, Andreas Weishaupt, Benedikt Grünewald, Thomas Wultsch, Andreas Reif, Manfred Gerlach, Ron Dirkx, Michele Solimena, Daniela Perani, Manfred Heckmann, Klaus V. Toyka, Franco Folli, Claudia Sommer |
| Abstract |
Anxiety is a heterogeneous behavioral domain playing a role in a variety of neuropsychiatric diseases. While anxiety is the cardinal symptom in disorders such as panic disorder, co-morbid anxious behavior can occur in a variety of diseases. Stiff person syndrome (SPS) is a CNS disorder characterized by increased muscle tone and prominent agoraphobia and anxiety. Most patients have high-titer antibodies against glutamate decarboxylase (GAD) 65. The pathogenic role of these autoantibodies is unclear. |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Germany | 1 | 2% |
| South Africa | 1 | 2% |
| Unknown | 61 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 19% |
| Other | 8 | 13% |
| Researcher | 7 | 11% |
| Student > Bachelor | 6 | 9% |
| Student > Doctoral Student | 4 | 6% |
| Other | 14 | 22% |
| Unknown | 13 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 36% |
| Agricultural and Biological Sciences | 8 | 13% |
| Neuroscience | 4 | 6% |
| Psychology | 4 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Other | 8 | 13% |
| Unknown | 15 | 23% |