| Title |
Resveratrol Inhibits Pancreatic Cancer Stem Cell Characteristics in Human and KrasG12D Transgenic Mice by Inhibiting Pluripotency Maintaining Factors and Epithelial-Mesenchymal Transition
|
|---|---|
| Published in |
PLOS ONE, January 2011
|
| DOI | 10.1371/journal.pone.0016530 |
| Pubmed ID | |
| Authors |
Sharmila Shankar, Dara Nall, Su-Ni Tang, Daniel Meeker, Jenna Passarini, Jay Sharma, Rakesh K. Srivastava |
| Abstract |
Cancer stem cells (CSCs) can proliferate and self-renew extensively due to their ability to express anti-apoptotic and drug resistant proteins, thus sustaining tumor growth. Therefore, the strategy to eradicate CSCs might have significant clinical implications. The objectives of this study were to examine the molecular mechanisms by which resveratrol inhibits stem cell characteristics of pancreatic CSCs derived from human primary tumors and Kras(G12D) transgenic mice. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 3% |
| Chile | 1 | <1% |
| Germany | 1 | <1% |
| Spain | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 141 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 33 | 22% |
| Student > Ph. D. Student | 27 | 18% |
| Student > Bachelor | 20 | 13% |
| Student > Master | 15 | 10% |
| Professor | 12 | 8% |
| Other | 22 | 15% |
| Unknown | 20 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 51 | 34% |
| Biochemistry, Genetics and Molecular Biology | 31 | 21% |
| Medicine and Dentistry | 26 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Engineering | 4 | 3% |
| Other | 8 | 5% |
| Unknown | 24 | 16% |