| Title |
Noninvasive Monitoring of Placenta-Specific Transgene Expression by Bioluminescence Imaging
|
|---|---|
| Published in |
PLOS ONE, January 2011
|
| DOI | 10.1371/journal.pone.0016348 |
| Pubmed ID | |
| Authors |
Xiujun Fan, Peigen Ren, Sabita Dhal, Gill Bejerano, Stuart B. Goodman, Maurice L. Druzin, Sanjiv S. Gambhir, Nihar R. Nayak |
| Abstract |
Placental dysfunction underlies numerous complications of pregnancy. A major obstacle to understanding the roles of potential mediators of placental pathology has been the absence of suitable methods for tissue-specific gene manipulation and sensitive assays for studying gene functions in the placentas of intact animals. We describe a sensitive and noninvasive method of repetitively tracking placenta-specific gene expression throughout pregnancy using lentivirus-mediated transduction of optical reporter genes in mouse blastocysts. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 3% |
| Unknown | 31 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 34% |
| Student > Ph. D. Student | 5 | 16% |
| Other | 4 | 13% |
| Student > Bachelor | 2 | 6% |
| Student > Master | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 5 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 38% |
| Medicine and Dentistry | 5 | 16% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Social Sciences | 1 | 3% |
| Chemistry | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 8 | 25% |