| Title |
Loss of Guanylyl Cyclase C (GCC) Signaling Leads to Dysfunctional Intestinal Barrier
|
|---|---|
| Published in |
PLOS ONE, January 2011
|
| DOI | 10.1371/journal.pone.0016139 |
| Pubmed ID | |
| Authors |
Xiaonan Han, Elizabeth Mann, Shila Gilbert, Yanfang Guan, Kris A. Steinbrecher, Marshall H. Montrose, Mitchell B. Cohen |
| Abstract |
Guanylyl Cyclase C (GCC) signaling via uroguanylin (UGN) and guanylin activation is a critical mediator of intestinal fluid homeostasis, intestinal cell proliferation/apoptosis, and tumorigenesis. As a mechanism for some of these effects, we hypothesized that GCC signaling mediates regulation of intestinal barrier function. |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Singapore | 1 | 2% |
| Belgium | 1 | 2% |
| Unknown | 42 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 27% |
| Researcher | 9 | 20% |
| Professor > Associate Professor | 4 | 9% |
| Student > Master | 4 | 9% |
| Student > Postgraduate | 3 | 7% |
| Other | 8 | 18% |
| Unknown | 5 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 27% |
| Agricultural and Biological Sciences | 11 | 24% |
| Biochemistry, Genetics and Molecular Biology | 9 | 20% |
| Immunology and Microbiology | 2 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 7 | 16% |