| Title |
Metabolic Activity and mRNA Levels of Human Cardiac CYP450s Involved in Drug Metabolism
|
|---|---|
| Published in |
PLOS ONE, December 2010
|
| DOI | 10.1371/journal.pone.0015666 |
| Pubmed ID | |
| Authors |
Veronique Michaud, Martin Frappier, Marie-Christine Dumas, Jacques Turgeon |
| Abstract |
Tissue-specific expression of CYP450s can regulate the intracellular concentration of drugs and explain inter-subject variability in drug action. The overall objective of our study was to determine in a large cohort of samples, mRNA levels and CYP450 activity expressed in the human heart. |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 2% |
| Unknown | 43 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 25% |
| Student > Ph. D. Student | 7 | 16% |
| Student > Bachelor | 5 | 11% |
| Other | 3 | 7% |
| Professor | 3 | 7% |
| Other | 8 | 18% |
| Unknown | 7 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 25% |
| Medicine and Dentistry | 10 | 23% |
| Agricultural and Biological Sciences | 9 | 20% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Decision Sciences | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 9 | 20% |