| Title |
Acetaminophen Induces Apoptosis in Rat Cortical Neurons
|
|---|---|
| Published in |
PLOS ONE, December 2010
|
| DOI | 10.1371/journal.pone.0015360 |
| Pubmed ID | |
| Authors |
Inmaculada Posadas, Pablo Santos, Almudena Blanco, Maríangeles Muñoz-Fernández, Valentín Ceña |
| Abstract |
Acetaminophen (AAP) is widely prescribed for treatment of mild pain and fever in western countries. It is generally considered a safe drug and the most frequently reported adverse effect associated with acetaminophen is hepatotoxicity, which generally occurs after acute overdose. During AAP overdose, encephalopathy might develop and contribute to morbidity and mortality. Our hypothesis is that AAP causes direct neuronal toxicity contributing to the general AAP toxicity syndrome. |
X Demographics
The data shown below were collected from the profiles of 63 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 30% |
| United Kingdom | 5 | 8% |
| Bolivia, Plurinational State of | 2 | 3% |
| Bosnia and Herzegovina | 1 | 2% |
| Netherlands | 1 | 2% |
| Australia | 1 | 2% |
| Guyana | 1 | 2% |
| Comoros | 1 | 2% |
| Thailand | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 31 | 49% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 51 | 81% |
| Scientists | 5 | 8% |
| Practitioners (doctors, other healthcare professionals) | 5 | 8% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 80 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 17% |
| Student > Bachelor | 14 | 17% |
| Student > Master | 10 | 12% |
| Student > Ph. D. Student | 8 | 10% |
| Student > Doctoral Student | 7 | 9% |
| Other | 16 | 20% |
| Unknown | 12 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 31% |
| Agricultural and Biological Sciences | 15 | 19% |
| Neuroscience | 10 | 12% |
| Psychology | 6 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Other | 8 | 10% |
| Unknown | 13 | 16% |