| Title |
Influenza A Virus Hemagglutinin Antibody Escape Promotes Neuraminidase Antigenic Variation and Drug Resistance
|
|---|---|
| Published in |
PLOS ONE, February 2011
|
| DOI | 10.1371/journal.pone.0015190 |
| Pubmed ID | |
| Authors |
Scott E. Hensley, Suman R. Das, James S. Gibbs, Adam L. Bailey, Loren M. Schmidt, Jack R. Bennink, Jonathan W. Yewdell |
| Abstract |
Drugs inhibiting the influenza A virus (IAV) neuraminidase (NA) are the cornerstone of anti-IAV chemotherapy and prophylaxis in man. Drug-resistant mutations in NA arise frequently in human isolates, limiting the therapeutic application of NA inhibitors. Here, we show that antibody-driven antigenic variation in one domain of the H1 hemagglutinin Sa site leads to compensatory mutations in NA, resulting in NA antigenic variation and acquisition of drug resistance. These findings indicate that influenza A virus resistance to NA inhibitors can potentially arise from antibody driven HA escape, confounding analysis of influenza NA evolution in nature. |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| United Kingdom | 1 | 1% |
| China | 1 | 1% |
| Vietnam | 1 | 1% |
| Unknown | 79 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 34% |
| Researcher | 22 | 26% |
| Student > Master | 8 | 9% |
| Student > Bachelor | 6 | 7% |
| Other | 5 | 6% |
| Other | 9 | 11% |
| Unknown | 6 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 34% |
| Biochemistry, Genetics and Molecular Biology | 14 | 16% |
| Immunology and Microbiology | 11 | 13% |
| Medicine and Dentistry | 5 | 6% |
| Computer Science | 3 | 4% |
| Other | 13 | 15% |
| Unknown | 10 | 12% |