Title |
MHC Mismatch Inhibits Neurogenesis and Neuron Maturation in Stem Cell Allografts
|
---|---|
Published in |
PLOS ONE, March 2011
|
DOI | 10.1371/journal.pone.0014787 |
Pubmed ID | |
Authors |
Zhiguo Chen, Lori K. Phillips, Elizabeth Gould, Jay Campisi, Star W. Lee, Brandi K. Ormerod, Monika Zwierzchoniewska, Olivia M. Martinez, Theo D. Palmer |
Abstract |
The role of histocompatibility and immune recognition in stem cell transplant therapy has been controversial, with many reports arguing that undifferentiated stem cells are protected from immune recognition due to the absence of major histocompatibility complex (MHC) markers. This argument is even more persuasive in transplantation into the central nervous system (CNS) where the graft rejection response is minimal. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 4% |
Japan | 1 | 2% |
Germany | 1 | 2% |
Unknown | 41 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 27% |
Researcher | 9 | 20% |
Student > Bachelor | 4 | 9% |
Student > Doctoral Student | 4 | 9% |
Professor | 3 | 7% |
Other | 7 | 16% |
Unknown | 6 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 29% |
Neuroscience | 8 | 18% |
Medicine and Dentistry | 7 | 16% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Psychology | 3 | 7% |
Other | 4 | 9% |
Unknown | 7 | 16% |