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MHC Mismatch Inhibits Neurogenesis and Neuron Maturation in Stem Cell Allografts

Overview of attention for article published in PLOS ONE, March 2011
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Title
MHC Mismatch Inhibits Neurogenesis and Neuron Maturation in Stem Cell Allografts
Published in
PLOS ONE, March 2011
DOI 10.1371/journal.pone.0014787
Pubmed ID
Authors

Zhiguo Chen, Lori K. Phillips, Elizabeth Gould, Jay Campisi, Star W. Lee, Brandi K. Ormerod, Monika Zwierzchoniewska, Olivia M. Martinez, Theo D. Palmer

Abstract

The role of histocompatibility and immune recognition in stem cell transplant therapy has been controversial, with many reports arguing that undifferentiated stem cells are protected from immune recognition due to the absence of major histocompatibility complex (MHC) markers. This argument is even more persuasive in transplantation into the central nervous system (CNS) where the graft rejection response is minimal.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
Japan 1 2%
Germany 1 2%
Unknown 41 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 27%
Researcher 9 20%
Student > Bachelor 4 9%
Student > Doctoral Student 4 9%
Professor 3 7%
Other 7 16%
Unknown 6 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 29%
Neuroscience 8 18%
Medicine and Dentistry 7 16%
Biochemistry, Genetics and Molecular Biology 3 7%
Psychology 3 7%
Other 4 9%
Unknown 7 16%