| Title |
The Development and Characterization of a Human Mesothelioma In Vitro 3D Model to Investigate Immunotoxin Therapy
|
|---|---|
| Published in |
PLOS ONE, January 2011
|
| DOI | 10.1371/journal.pone.0014640 |
| Pubmed ID | |
| Authors |
Xinran Xiang, Yen Phung, Mingqian Feng, Kunio Nagashima, Jingli Zhang, V. Courtney Broaddus, Raffit Hassan, David FitzGerald, Mitchell Ho |
| Abstract |
Tumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates. Tumor microenvironments, however, are difficult to study in vitro. Cells cultured as monolayers exhibit less resistance to therapy than those grown in vivo and an alternative research model more representative of the in vivo tumor is more desirable. SS1P is an immunotoxin composed of the Fv portion of a mesothelin-specific antibody fused to a bacterial toxin that is presently undergoing clinical trials in mesothelioma. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 3 | 4% |
| United States | 1 | 1% |
| France | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 72 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 27% |
| Student > Ph. D. Student | 17 | 22% |
| Student > Postgraduate | 9 | 12% |
| Student > Master | 8 | 10% |
| Professor | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 9 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 42% |
| Biochemistry, Genetics and Molecular Biology | 11 | 14% |
| Medicine and Dentistry | 11 | 14% |
| Engineering | 5 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 12 | 15% |