| Title |
Sildenafil Reduces Insulin-Resistance in Human Endothelial Cells
|
|---|---|
| Published in |
PLOS ONE, January 2011
|
| DOI | 10.1371/journal.pone.0014542 |
| Pubmed ID | |
| Authors |
Caterina Mammi, Donatella Pastore, Marco F. Lombardo, Francesca Ferrelli, Massimiliano Caprio, Claudia Consoli, Manfredi Tesauro, Lucia Gatta, Massimo Fini, Massimo Federici, Paolo Sbraccia, Giulia Donadel, Alfonso Bellia, Giuseppe M. Rosano, Andrea Fabbri, Davide Lauro |
| Abstract |
The efficacy of Phosphodiesterase 5 (PDE5) inhibitors to re-establish endothelial function is reduced in diabetic patients. Recent evidences suggest that therapy with PDE5 inhibitors, i.e. sildenafil, may increase the expression of nitric oxide synthase (NOS) proteins in the heart and cardiomyocytes. In this study we analyzed the effect of sildenafil on endothelial cells in insulin resistance conditions in vitro. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 2% |
| Italy | 1 | 2% |
| Brazil | 1 | 2% |
| Singapore | 1 | 2% |
| Japan | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 49 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 24% |
| Student > Ph. D. Student | 7 | 13% |
| Student > Master | 7 | 13% |
| Professor | 4 | 7% |
| Student > Postgraduate | 4 | 7% |
| Other | 11 | 20% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 29% |
| Agricultural and Biological Sciences | 15 | 27% |
| Biochemistry, Genetics and Molecular Biology | 6 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 9% |
| Veterinary Science and Veterinary Medicine | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 9 | 16% |