Title |
Immunopotentiation of Trivalent Influenza Vaccine When Given with VAX102, a Recombinant Influenza M2e Vaccine Fused to the TLR5 Ligand Flagellin
|
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Published in |
PLOS ONE, December 2010
|
DOI | 10.1371/journal.pone.0014442 |
Pubmed ID | |
Authors |
H. Keipp Talbot, Michael T. Rock, Casey Johnson, Lynda Tussey, Uma Kavita, Anita Shanker, Alan R. Shaw, David N. Taylor |
Abstract |
Currently controversy exists about the immunogenicity of seasonal trivalent influenza vaccine in certain populations, especially the elderly. STF2.4×M2e (VAX102) is a recombinant fusion protein that links four copies of the ectodomain of influenza virus matrix protein 2 (M2e) antigen to Salmonella typhimurium flagellin, a TLR5 ligand. The objectives of this study were to assess the feasibility of giving VAX102 and TIV in combination in an effort to achieve greater immunogenicity and to provide cross-protection. |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
India | 1 | 2% |
Sweden | 1 | 2% |
Unknown | 56 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 22% |
Researcher | 12 | 20% |
Student > Bachelor | 6 | 10% |
Student > Master | 6 | 10% |
Student > Postgraduate | 3 | 5% |
Other | 8 | 13% |
Unknown | 12 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 23% |
Agricultural and Biological Sciences | 10 | 17% |
Biochemistry, Genetics and Molecular Biology | 8 | 13% |
Immunology and Microbiology | 5 | 8% |
Veterinary Science and Veterinary Medicine | 2 | 3% |
Other | 8 | 13% |
Unknown | 13 | 22% |