| Title |
High ALDH Activity Identifies Chemotherapy-Resistant Ewing's Sarcoma Stem Cells That Retain Sensitivity to EWS-FLI1 Inhibition
|
|---|---|
| Published in |
PLOS ONE, November 2010
|
| DOI | 10.1371/journal.pone.0013943 |
| Pubmed ID | |
| Authors |
Ola Awad, Jason T. Yustein, Preeti Shah, Naheed Gul, Varalakshmi Katuri, Alison O'Neill, Yali Kong, Milton L. Brown, Jeffrey A. Toretsky, David M. Loeb |
| Abstract |
Cancer stem cells are a chemotherapy-resistant population capable of self-renewal and of regenerating the bulk tumor, thereby causing relapse and patient death. Ewing's sarcoma, the second most common form of bone tumor in adolescents and young adults, follows a clinical pattern consistent with the Cancer Stem Cell model - remission is easily achieved, even for patients with metastatic disease, but relapse remains frequent and is usually fatal. |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 3 | 3% |
| United States | 2 | 2% |
| Portugal | 1 | 1% |
| Italy | 1 | 1% |
| Netherlands | 1 | 1% |
| United Kingdom | 1 | 1% |
| Luxembourg | 1 | 1% |
| Unknown | 88 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 30% |
| Researcher | 16 | 16% |
| Student > Bachelor | 10 | 10% |
| Student > Master | 9 | 9% |
| Student > Doctoral Student | 6 | 6% |
| Other | 15 | 15% |
| Unknown | 13 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 30% |
| Medicine and Dentistry | 21 | 21% |
| Biochemistry, Genetics and Molecular Biology | 16 | 16% |
| Chemistry | 4 | 4% |
| Engineering | 3 | 3% |
| Other | 9 | 9% |
| Unknown | 16 | 16% |