| Title |
Static Magnetic Field Exposure Reproduces Cellular Effects of the Parkinson's Disease Drug Candidate ZM241385
|
|---|---|
| Published in |
PLOS ONE, November 2010
|
| DOI | 10.1371/journal.pone.0013883 |
| Pubmed ID | |
| Authors |
Zhiyun Wang, Pao-Lin Che, Jian Du, Barbara Ha, Kevin J. Yarema |
| Abstract |
This study was inspired by coalescing evidence that magnetic therapy may be a viable treatment option for certain diseases. This premise is based on the ability of moderate strength fields (i.e., 0.1 to 1 Tesla) to alter the biophysical properties of lipid bilayers and in turn modulate cellular signaling pathways. In particular, previous results from our laboratory (Wang et al., BMC Genomics, 10, 356 (2009)) established that moderate strength static magnetic field (SMF) exposure altered cellular endpoints associated with neuronal function and differentiation. Building on this background, the current paper investigated SMF by focusing on the adenosine A(2A) receptor (A(2A)R) in the PC12 rat adrenal pheochromocytoma cell line that displays metabolic features of Parkinson's disease (PD). |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Japan | 1 | 1% |
| Unknown | 67 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 16% |
| Student > Bachelor | 10 | 14% |
| Student > Ph. D. Student | 10 | 14% |
| Student > Doctoral Student | 8 | 11% |
| Student > Master | 8 | 11% |
| Other | 16 | 23% |
| Unknown | 7 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 26% |
| Medicine and Dentistry | 16 | 23% |
| Neuroscience | 6 | 9% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Engineering | 4 | 6% |
| Other | 13 | 19% |
| Unknown | 8 | 11% |