| Title |
Structural Studies of the Tandem Tudor Domains of Fragile X Mental Retardation Related Proteins FXR1 and FXR2
|
|---|---|
| Published in |
PLOS ONE, November 2010
|
| DOI | 10.1371/journal.pone.0013559 |
| Pubmed ID | |
| Authors |
Melanie A. Adams-Cioaba, Yahong Guo, ChuanBing Bian, Maria F. Amaya, Robert Lam, Gregory A. Wasney, Masoud Vedadi, Chao Xu, Jinrong Min |
| Abstract |
Expansion of the CGG trinucleotide repeat in the 5'-untranslated region of the FMR1, fragile X mental retardation 1, gene results in suppression of protein expression for this gene and is the underlying cause of Fragile X syndrome. In unaffected individuals, the FMRP protein, together with two additional paralogues (Fragile X Mental Retardation Syndrome-related Protein 1 and 2), associates with mRNA to form a ribonucleoprotein complex in the nucleus that is transported to dendrites and spines of neuronal cells. It is thought that the fragile X family of proteins contributes to the regulation of protein synthesis at sites where mRNAs are locally translated in response to stimuli. |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 77 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 34% |
| Researcher | 16 | 20% |
| Student > Bachelor | 8 | 10% |
| Student > Master | 5 | 6% |
| Student > Doctoral Student | 3 | 4% |
| Other | 9 | 11% |
| Unknown | 11 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 22 | 28% |
| Agricultural and Biological Sciences | 22 | 28% |
| Chemistry | 7 | 9% |
| Neuroscience | 5 | 6% |
| Computer Science | 3 | 4% |
| Other | 7 | 9% |
| Unknown | 13 | 16% |