| Title |
Abnormalities in Oxygen Sensing Define Early and Late Onset Preeclampsia as Distinct Pathologies
|
|---|---|
| Published in |
PLOS ONE, October 2010
|
| DOI | 10.1371/journal.pone.0013288 |
| Pubmed ID | |
| Authors |
Alessandro Rolfo, Ariel Many, Antonella Racano, Reshef Tal, Andrea Tagliaferro, Francesca Ietta, Jinxia Wang, Martin Post, Isabella Caniggia |
| Abstract |
The pathogenesis of preeclampsia, a serious pregnancy disorder, is still elusive and its treatment empirical. Hypoxia Inducible Factor-1 (HIF-1) is crucial for placental development and early detection of aberrant regulatory mechanisms of HIF-1 could impact on the diagnosis and management of preeclampsia. HIF-1α stability is controlled by O(2)-sensing enzymes including prolyl hydroxylases (PHDs), Factor Inhibiting HIF (FIH), and E3 ligases Seven In Absentia Homologues (SIAHs). Here we investigated early- (E-PE) and late-onset (L-PE) human preeclamptic placentae and their ability to sense changes in oxygen tension occurring during normal placental development. |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Mexico | 1 | 2% |
| Ukraine | 1 | 2% |
| Unknown | 58 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 20% |
| Researcher | 10 | 16% |
| Student > Doctoral Student | 7 | 11% |
| Student > Bachelor | 6 | 10% |
| Student > Master | 6 | 10% |
| Other | 11 | 18% |
| Unknown | 9 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 38% |
| Agricultural and Biological Sciences | 13 | 21% |
| Biochemistry, Genetics and Molecular Biology | 8 | 13% |
| Nursing and Health Professions | 2 | 3% |
| Engineering | 2 | 3% |
| Other | 6 | 10% |
| Unknown | 7 | 11% |