| Title |
Discovery of a Novel and Rich Source of Gluten-Degrading Microbial Enzymes in the Oral Cavity
|
|---|---|
| Published in |
PLOS ONE, October 2010
|
| DOI | 10.1371/journal.pone.0013264 |
| Pubmed ID | |
| Authors |
Eva J. Helmerhorst, Maram Zamakhchari, Detlef Schuppan, Frank G. Oppenheim |
| Abstract |
Celiac disease is a T cell mediated-inflammatory enteropathy caused by the ingestion of gluten in genetically predisposed individuals carrying HLA-DQ2 or HLA-DQ8. The immunogenic gliadin epitopes, containing multiple glutamine and proline residues, are largely resistant to degradation by gastric and intestinal proteases. Salivary microorganisms however exhibit glutamine endoprotease activity, discovered towards glutamine- and proline-rich salivary proteins. The aim was to explore if gliadins can serve as substrates for oral microbial enzymes. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| United Kingdom | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
| Scientists | 1 | 33% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Hungary | 1 | 1% |
| India | 1 | 1% |
| Netherlands | 1 | 1% |
| Unknown | 88 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 18 | 19% |
| Researcher | 15 | 16% |
| Student > Ph. D. Student | 11 | 12% |
| Student > Master | 10 | 11% |
| Student > Doctoral Student | 5 | 5% |
| Other | 15 | 16% |
| Unknown | 19 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 25% |
| Biochemistry, Genetics and Molecular Biology | 17 | 18% |
| Medicine and Dentistry | 12 | 13% |
| Immunology and Microbiology | 5 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 8 | 9% |
| Unknown | 25 | 27% |