Title |
Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line
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Published in |
PLOS ONE, October 2010
|
DOI | 10.1371/journal.pone.0013247 |
Pubmed ID | |
Authors |
Keiichi Ohshima, Kanako Inoue, Akemi Fujiwara, Keiichi Hatakeyama, Kaori Kanto, Yuko Watanabe, Koji Muramatsu, Yorikane Fukuda, Shun-ichiro Ogura, Ken Yamaguchi, Tohru Mochizuki |
Abstract |
Exosomes play a major role in cell-to-cell communication, targeting cells to transfer exosomal molecules including proteins, mRNAs, and microRNAs (miRNAs) by an endocytosis-like pathway. miRNAs are small noncoding RNA molecules on average 22 nucleotides in length that regulate numerous biological processes including cancer pathogenesis and mediate gene down-regulation by targeting mRNAs to induce RNA degradation and/or interfering with translation. Recent reports imply that miRNAs can be stably detected in circulating plasma and serum since miRNAs are packaged by exosomes to be protected from RNA degradation. Thus, profiling exosomal miRNAs are in need to clarify intercellular signaling and discover a novel disease marker as well. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 2% |
France | 2 | <1% |
Netherlands | 2 | <1% |
India | 2 | <1% |
Japan | 2 | <1% |
United Kingdom | 2 | <1% |
Canada | 1 | <1% |
Argentina | 1 | <1% |
Germany | 1 | <1% |
Other | 4 | 1% |
Unknown | 371 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 99 | 25% |
Researcher | 84 | 21% |
Student > Bachelor | 52 | 13% |
Student > Master | 45 | 11% |
Professor > Associate Professor | 19 | 5% |
Other | 50 | 13% |
Unknown | 45 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 143 | 36% |
Biochemistry, Genetics and Molecular Biology | 86 | 22% |
Medicine and Dentistry | 55 | 14% |
Engineering | 11 | 3% |
Immunology and Microbiology | 10 | 3% |
Other | 36 | 9% |
Unknown | 53 | 13% |