| Title |
Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression
|
|---|---|
| Published in |
PLOS ONE, September 2010
|
| DOI | 10.1371/journal.pone.0012862 |
| Pubmed ID | |
| Authors |
Sher L. Hendrickson, James A. Lautenberger, Leslie Wei Chinn, Michael Malasky, Efe Sezgin, Lawrence A. Kingsley, James J. Goedert, Gregory D. Kirk, Edward D. Gomperts, Susan P. Buchbinder, Jennifer L. Troyer, Stephen J. O'Brien |
| Abstract |
The human mitochondrial genome includes only 13 coding genes while nuclear-encoded genes account for 99% of proteins responsible for mitochondrial morphology, redox regulation, and energetics. Mitochondrial pathogenesis occurs in HIV patients and genetically, mitochondrial DNA haplogroups with presumed functional differences have been associated with differential AIDS progression. |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| United Kingdom | 2 | 1% |
| South Africa | 1 | <1% |
| Germany | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Austria | 1 | <1% |
| Unknown | 134 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 21% |
| Student > Ph. D. Student | 23 | 16% |
| Student > Bachelor | 17 | 12% |
| Professor | 13 | 9% |
| Student > Master | 13 | 9% |
| Other | 30 | 21% |
| Unknown | 17 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 55 | 38% |
| Biochemistry, Genetics and Molecular Biology | 32 | 22% |
| Medicine and Dentistry | 16 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Neuroscience | 4 | 3% |
| Other | 12 | 8% |
| Unknown | 20 | 14% |