Title |
The Crystal Structure of Toxoplasma gondii Pyruvate Kinase 1
|
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Published in |
PLOS ONE, September 2010
|
DOI | 10.1371/journal.pone.0012736 |
Pubmed ID | |
Authors |
Rebecca Bakszt, Amy Wernimont, Abdellah Allali-Hassani, Man Wai Mok, Tanya Hills, Raymond Hui, Juan C. Pizarro |
Abstract |
Pyruvate kinase (PK), which catalyzes the final step in glycolysis converting phosphoenolpyruvate to pyruvate, is a central metabolic regulator in most organisms. Consequently PK represents an attractive therapeutic target in cancer and human pathogens, like Apicomplexans. The phylum Aplicomplexa, a group of exclusively parasitic organisms, includes the genera Plasmodium, Cryptosporidium and Toxoplasma, the etiological agents of malaria, cryptosporidiosis and toxoplasmosis respectively. Toxoplasma gondii infection causes a mild illness and is a very common infection affecting nearly one third of the world's population. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
China | 1 | 3% |
Pakistan | 1 | 3% |
Australia | 1 | 3% |
Unknown | 30 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 26% |
Researcher | 6 | 18% |
Student > Master | 6 | 18% |
Student > Doctoral Student | 3 | 9% |
Student > Bachelor | 2 | 6% |
Other | 5 | 15% |
Unknown | 3 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 44% |
Biochemistry, Genetics and Molecular Biology | 4 | 12% |
Medicine and Dentistry | 4 | 12% |
Nursing and Health Professions | 1 | 3% |
Chemical Engineering | 1 | 3% |
Other | 4 | 12% |
Unknown | 5 | 15% |