| Title |
The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK
|
|---|---|
| Published in |
PLOS ONE, August 2010
|
| DOI | 10.1371/journal.pone.0012335 |
| Pubmed ID | |
| Authors |
Brian J. Krueger, Katayoun Varzavand, Jeffrey J. Cooper, David H. Price |
| Abstract |
The positive transcription elongation factor, P-TEFb, is required for the production of mRNAs, however the majority of the factor is present in the 7SK snRNP where it is inactivated by HEXIM1. Expression of HIV-1 Tat leads to release of P-TEFb and HEXIM1 from the 7SK snRNP in vivo, but the release mechanisms are unclear. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| India | 1 | <1% |
| United States | 1 | <1% |
| France | 1 | <1% |
| Unknown | 102 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 36% |
| Student > Master | 12 | 11% |
| Student > Bachelor | 11 | 10% |
| Researcher | 9 | 8% |
| Student > Doctoral Student | 7 | 7% |
| Other | 11 | 10% |
| Unknown | 18 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 36 | 34% |
| Biochemistry, Genetics and Molecular Biology | 32 | 30% |
| Chemistry | 9 | 8% |
| Medicine and Dentistry | 4 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 6 | 6% |
| Unknown | 18 | 17% |