| Title |
Bcl-2 Regulates HIF-1α Protein Stabilization in Hypoxic Melanoma Cells via the Molecular Chaperone HSP90
|
|---|---|
| Published in |
PLOS ONE, July 2010
|
| DOI | 10.1371/journal.pone.0011772 |
| Pubmed ID | |
| Authors |
Daniela Trisciuoglio, Chiara Gabellini, Marianna Desideri, Elio Ziparo, Gabriella Zupi, Donatella Del Bufalo |
| Abstract |
Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is a critical mediator of the cellular response to hypoxia. Enhanced levels of HIF-1alpha, the oxygen-regulated subunit of HIF-1, is often associated with increased tumour angiogenesis, metastasis, therapeutic resistance and poor prognosis. It is in this context that we previously demonstrated that under hypoxia, bcl-2 protein promotes HIF-1/Vascular Endothelial Growth Factor (VEGF)-mediated tumour angiogenesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 2 | 3% |
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Poland | 1 | 1% |
| Unknown | 68 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 33% |
| Researcher | 13 | 18% |
| Student > Bachelor | 6 | 8% |
| Professor | 4 | 5% |
| Student > Master | 4 | 5% |
| Other | 8 | 11% |
| Unknown | 14 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 32% |
| Medicine and Dentistry | 15 | 21% |
| Biochemistry, Genetics and Molecular Biology | 13 | 18% |
| Engineering | 2 | 3% |
| Chemistry | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 13 | 18% |