| Title |
Otx2 Gene Deletion in Adult Mouse Retina Induces Rapid RPE Dystrophy and Slow Photoreceptor Degeneration
|
|---|---|
| Published in |
PLOS ONE, July 2010
|
| DOI | 10.1371/journal.pone.0011673 |
| Pubmed ID | |
| Authors |
Francis Béby, Michael Housset, Nicolas Fossat, Coralie Le Greneur, Frédéric Flamant, Pierre Godement, Thomas Lamonerie |
| Abstract |
Many developmental genes are still active in specific tissues after development is completed. This is the case for the homeobox gene Otx2, an essential actor of forebrain and head development. In adult mouse, Otx2 is strongly expressed in the retina. Mutations of this gene in humans have been linked to severe ocular malformation and retinal diseases. It is, therefore, important to explore its post-developmental functions. In the mature retina, Otx2 is expressed in three cell types: bipolar and photoreceptor cells that belong to the neural retina and retinal pigment epithelium (RPE), a neighbour structure that forms a tightly interdependent functional unit together with photoreceptor cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| France | 1 | 1% |
| South Africa | 1 | 1% |
| Unknown | 65 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 29% |
| Student > Ph. D. Student | 18 | 26% |
| Student > Master | 7 | 10% |
| Professor | 4 | 6% |
| Professor > Associate Professor | 4 | 6% |
| Other | 9 | 13% |
| Unknown | 6 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 43% |
| Biochemistry, Genetics and Molecular Biology | 14 | 21% |
| Neuroscience | 8 | 12% |
| Medicine and Dentistry | 7 | 10% |
| Unspecified | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 7 | 10% |