| Title |
Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice
|
|---|---|
| Published in |
PLOS ONE, July 2010
|
| DOI | 10.1371/journal.pone.0011528 |
| Pubmed ID | |
| Authors |
Sung-Wuk Jang, Xia Liu, Chi Bun Chan, Stefan A. France, Iqbal Sayeed, Wenxue Tang, Xi Lin, Ge Xiao, Raul Andero, Qiang Chang, Kerry J. Ressler, Keqiang Ye |
| Abstract |
Gedunin, a family of natural products from the Indian neem tree, possess a variety of biological activities. Here we report the discovery of deoxygedunin, which activates the mouse TrkB receptor and its downstream signaling cascades. Deoxygedunin is orally available and activates TrkB in mouse brain in a BDNF-independent way. Strikingly, it prevents the degeneration of vestibular ganglion in BDNF -/- pups. Moreover, deoxygedunin robustly protects rat neurons from cell death in a TrkB-dependent manner. Further, administration of deoxygedunin into mice displays potent neuroprotective, anti-depressant and learning enhancement effects, all of which are mediated by the TrkB receptor. Hence, deoxygedunin imitates BDNF's biological activities through activating TrkB, providing a powerful therapeutic tool for treatment of various neurological diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| India | 1 | <1% |
| United States | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 99 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 25% |
| Researcher | 20 | 19% |
| Student > Master | 16 | 16% |
| Professor > Associate Professor | 6 | 6% |
| Student > Bachelor | 5 | 5% |
| Other | 13 | 13% |
| Unknown | 17 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 32% |
| Chemistry | 13 | 13% |
| Medicine and Dentistry | 10 | 10% |
| Neuroscience | 8 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Other | 14 | 14% |
| Unknown | 19 | 18% |