| Title |
Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice
|
|---|---|
| Published in |
PLOS ONE, July 2010
|
| DOI | 10.1371/journal.pone.0011468 |
| Pubmed ID | |
| Authors |
Asimina Hiona, Alberto Sanz, Gregory C. Kujoth, Reinald Pamplona, Arnold Y. Seo, Tim Hofer, Shinichi Someya, Takuya Miyakawa, Chie Nakayama, Alejandro K. Samhan-Arias, Stephane Servais, Jamie L. Barger, Manuel Portero-Otín, Masaru Tanokura, Tomas A. Prolla, Christiaan Leeuwenburgh |
| Abstract |
Aging results in a progressive loss of skeletal muscle, a condition known as sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal muscle and correlate with muscle loss, although no causal relationship has been established. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 295 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| Chile | 1 | <1% |
| Norway | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| China | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 287 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 54 | 18% |
| Researcher | 54 | 18% |
| Student > Bachelor | 41 | 14% |
| Student > Master | 27 | 9% |
| Professor > Associate Professor | 11 | 4% |
| Other | 45 | 15% |
| Unknown | 63 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 79 | 27% |
| Biochemistry, Genetics and Molecular Biology | 70 | 24% |
| Medicine and Dentistry | 32 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 4% |
| Neuroscience | 10 | 3% |
| Other | 20 | 7% |
| Unknown | 73 | 25% |