| Title |
Liposome-siRNA-Peptide Complexes Cross the Blood-Brain Barrier and Significantly Decrease PrPC on Neuronal Cells and PrPRES in Infected Cell Cultures
|
|---|---|
| Published in |
PLOS ONE, June 2010
|
| DOI | 10.1371/journal.pone.0011085 |
| Pubmed ID | |
| Authors |
Bruce Pulford, Natalia Reim, Aimee Bell, Jessica Veatch, Genevieve Forster, Heather Bender, Crystal Meyerett, Scott Hafeman, Brady Michel, Theodore Johnson, A. Christy Wyckoff, Gino Miele, Christian Julius, Jan Kranich, Alan Schenkel, Steven Dow, Mark D. Zabel |
| Abstract |
Recent advances toward an effective therapy for prion diseases employ RNA interference to suppress PrP(C) expression and subsequent prion neuropathology, exploiting the phenomenon that disease severity and progression correlate with host PrP(C) expression levels. However, delivery of lentivirus encoding PrP shRNA has demonstrated only modest efficacy in vivo. |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 4% |
| India | 2 | 2% |
| Brazil | 1 | <1% |
| Belgium | 1 | <1% |
| South Africa | 1 | <1% |
| Russia | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 91 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 29% |
| Student > Ph. D. Student | 29 | 28% |
| Student > Master | 8 | 8% |
| Professor > Associate Professor | 7 | 7% |
| Student > Bachelor | 5 | 5% |
| Other | 12 | 12% |
| Unknown | 11 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 28% |
| Biochemistry, Genetics and Molecular Biology | 20 | 20% |
| Chemistry | 8 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
| Medicine and Dentistry | 7 | 7% |
| Other | 20 | 20% |
| Unknown | 11 | 11% |