| Title |
Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs
|
|---|---|
| Published in |
PLOS ONE, June 2010
|
| DOI | 10.1371/journal.pone.0011013 |
| Pubmed ID | |
| Authors |
Melissa C. Paoloni, Christina Mazcko, Elizabeth Fox, Timothy Fan, Susan Lana, William Kisseberth, David M. Vail, Kaylee Nuckolls, Tanasa Osborne, Samuel Yalkowsy, Daniel Gustafson, Yunkai Yu, Liang Cao, Chand Khanna |
| Abstract |
Signaling through the mTOR pathway contributes to growth, progression and chemoresistance of several cancers. Accordingly, inhibitors have been developed as potentially valuable therapeutics. Their optimal development requires consideration of dose, regimen, biomarkers and a rationale for their use in combination with other agents. Using the infrastructure of the Comparative Oncology Trials Consortium many of these complex questions were asked within a relevant population of dogs with osteosarcoma to inform the development of mTOR inhibitors for future use in pediatric osteosarcoma patients. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Russia | 1 | <1% |
| Unknown | 113 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 18% |
| Other | 18 | 16% |
| Student > Master | 10 | 9% |
| Student > Ph. D. Student | 9 | 8% |
| Student > Bachelor | 9 | 8% |
| Other | 32 | 28% |
| Unknown | 17 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Veterinary Science and Veterinary Medicine | 32 | 28% |
| Medicine and Dentistry | 29 | 25% |
| Agricultural and Biological Sciences | 15 | 13% |
| Biochemistry, Genetics and Molecular Biology | 8 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Other | 8 | 7% |
| Unknown | 20 | 17% |