Title |
The Acid Test of Fluoride: How pH Modulates Toxicity
|
---|---|
Published in |
PLOS ONE, May 2010
|
DOI | 10.1371/journal.pone.0010895 |
Pubmed ID | |
Authors |
Ramaswamy Sharma, Masahiro Tsuchiya, Ziedonis Skobe, Bakhos A. Tannous, John D. Bartlett |
Abstract |
It is not known why the ameloblasts responsible for dental enamel formation are uniquely sensitive to fluoride (F(-)). Herein, we present a novel theory with supporting data to show that the low pH environment of maturating stage ameloblasts enhances their sensitivity to a given dose of F(-). Enamel formation is initiated in a neutral pH environment (secretory stage); however, the pH can fall to below 6.0 as most of the mineral precipitates (maturation stage). Low pH can facilitate entry of F(-) into cells. Here, we asked if F(-) was more toxic at low pH, as measured by increased cell stress and decreased cell function. |
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United Kingdom | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 42 | 98% |
Demographic breakdown
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Researcher | 8 | 19% |
Student > Bachelor | 5 | 12% |
Student > Doctoral Student | 5 | 12% |
Student > Postgraduate | 4 | 9% |
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Other | 8 | 19% |
Unknown | 10 | 23% |
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Chemistry | 5 | 12% |
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Environmental Science | 3 | 7% |
Other | 6 | 14% |
Unknown | 12 | 28% |