Title |
Exon Exchange Approach to Repair Duchenne Dystrophin Transcripts
|
---|---|
Published in |
PLOS ONE, May 2010
|
DOI | 10.1371/journal.pone.0010894 |
Pubmed ID | |
Authors |
Stéphanie Lorain, Cécile Peccate, Maëva Le Hir, Luis Garcia |
Abstract |
Trans-splicing strategies for mRNA repair involve engineered transcripts designed to anneal target mRNAs in order to interfere with their natural splicing, giving rise to mRNA chimeras where endogenous mutated exons have been replaced by exogenous replacement sequences. A number of trans-splicing molecules have already been proposed for replacing either the 5' or the 3' part of transcripts to be repaired. Here, we show the feasibility of RNA surgery by using a double trans-splicing approach allowing the specific substitution of a given mutated exon. |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Sweden | 1 | 2% |
France | 1 | 2% |
Germany | 1 | 2% |
Unknown | 44 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 26% |
Student > Ph. D. Student | 8 | 17% |
Professor | 5 | 11% |
Student > Bachelor | 4 | 9% |
Student > Master | 4 | 9% |
Other | 8 | 17% |
Unknown | 6 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 24 | 51% |
Medicine and Dentistry | 5 | 11% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Neuroscience | 2 | 4% |
Unspecified | 1 | 2% |
Other | 4 | 9% |
Unknown | 7 | 15% |