| Title |
Bare Bones Pattern Formation: A Core Regulatory Network in Varying Geometries Reproduces Major Features of Vertebrate Limb Development and Evolution
|
|---|---|
| Published in |
PLOS ONE, May 2010
|
| DOI | 10.1371/journal.pone.0010892 |
| Pubmed ID | |
| Authors |
Jianfeng Zhu, Yong-Tao Zhang, Mark S. Alber, Stuart A. Newman |
| Abstract |
Major unresolved questions regarding vertebrate limb development concern how the numbers of skeletal elements along the proximodistal (P-D) and anteroposterior (A-P) axes are determined and how the shape of a growing limb affects skeletal element formation. There is currently no generally accepted model for these patterning processes, but recent work on cartilage development (chondrogenesis) indicates that precartilage tissue self-organizes into nodular patterns by cell-molecular circuitry with local auto-activating and lateral inhibitory (LALI) properties. This process is played out in the developing limb in the context of a gradient of fibroblast growth factor (FGF) emanating from the apical ectodermal ridge (AER). |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 3% |
| Argentina | 2 | 1% |
| Brazil | 2 | 1% |
| Netherlands | 1 | <1% |
| South Africa | 1 | <1% |
| Canada | 1 | <1% |
| France | 1 | <1% |
| Gambia | 1 | <1% |
| Mexico | 1 | <1% |
| Other | 2 | 1% |
| Unknown | 129 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 20% |
| Researcher | 26 | 18% |
| Student > Master | 21 | 14% |
| Student > Bachelor | 18 | 12% |
| Professor | 9 | 6% |
| Other | 33 | 23% |
| Unknown | 10 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 71 | 49% |
| Biochemistry, Genetics and Molecular Biology | 16 | 11% |
| Earth and Planetary Sciences | 7 | 5% |
| Medicine and Dentistry | 7 | 5% |
| Engineering | 7 | 5% |
| Other | 24 | 16% |
| Unknown | 14 | 10% |