| Title |
Natural Selection of Human Embryos: Decidualizing Endometrial Stromal Cells Serve as Sensors of Embryo Quality upon Implantation
|
|---|---|
| Published in |
PLOS ONE, April 2010
|
| DOI | 10.1371/journal.pone.0010258 |
| Pubmed ID | |
| Authors |
Gijs Teklenburg, Madhuri Salker, Mariam Molokhia, Stuart Lavery, Geoffrey Trew, Tepchongchit Aojanepong, Helen J. Mardon, Amali U. Lokugamage, Raj Rai, Christian Landles, Bernard A. J. Roelen, Siobhan Quenby, Ewart W. Kuijk, Annemieke Kavelaars, Cobi J. Heijnen, Lesley Regan, Jan J. Brosens, Nick S. Macklon |
| Abstract |
Pregnancy is widely viewed as dependent upon an intimate dialogue, mediated by locally secreted factors between a developmentally competent embryo and a receptive endometrium. Reproductive success in humans is however limited, largely because of the high prevalence of chromosomally abnormal preimplantation embryos. Moreover, the transient period of endometrial receptivity in humans uniquely coincides with differentiation of endometrial stromal cells (ESCs) into highly specialized decidual cells, which in the absence of pregnancy invariably triggers menstruation. The role of cyclic decidualization of the endometrium in the implantation process and the nature of the decidual cytokines and growth factors that mediate the crosstalk with the embryo are unknown. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 33% |
| Australia | 1 | 8% |
| Cyprus | 1 | 8% |
| Peru | 1 | 8% |
| Unknown | 5 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 92% |
| Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 238 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 2 | <1% |
| United States | 2 | <1% |
| Argentina | 2 | <1% |
| Australia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Russia | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 228 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 47 | 20% |
| Student > Bachelor | 30 | 13% |
| Student > Master | 25 | 11% |
| Researcher | 24 | 10% |
| Professor | 12 | 5% |
| Other | 38 | 16% |
| Unknown | 62 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 62 | 26% |
| Medicine and Dentistry | 40 | 17% |
| Biochemistry, Genetics and Molecular Biology | 30 | 13% |
| Social Sciences | 6 | 3% |
| Nursing and Health Professions | 4 | 2% |
| Other | 26 | 11% |
| Unknown | 70 | 29% |