| Title |
Uncovering Molecular Biomarkers That Correlate Cognitive Decline with the Changes of Hippocampus' Gene Expression Profiles in Alzheimer's Disease
|
|---|---|
| Published in |
PLOS ONE, April 2010
|
| DOI | 10.1371/journal.pone.0010153 |
| Pubmed ID | |
| Authors |
Martín Gómez Ravetti, Osvaldo A. Rosso, Regina Berretta, Pablo Moscato |
| Abstract |
Alzheimer's disease (AD) is characterized by a neurodegenerative progression that alters cognition. On a phenotypical level, cognition is evaluated by means of the MiniMental State Examination (MMSE) and the post-mortem examination of Neurofibrillary Tangle count (NFT) helps to confirm an AD diagnostic. The MMSE evaluates different aspects of cognition including orientation, short-term memory (retention and recall), attention and language. As there is a normal cognitive decline with aging, and death is the final state on which NFT can be counted, the identification of brain gene expression biomarkers from these phenotypical measures has been elusive. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 204 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Germany | 2 | <1% |
| Norway | 1 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| United Kingdom | 1 | <1% |
| Ireland | 1 | <1% |
| Spain | 1 | <1% |
| Canada | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 190 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 23% |
| Researcher | 41 | 20% |
| Student > Bachelor | 20 | 10% |
| Student > Master | 17 | 8% |
| Professor | 10 | 5% |
| Other | 40 | 20% |
| Unknown | 30 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 54 | 26% |
| Biochemistry, Genetics and Molecular Biology | 24 | 12% |
| Medicine and Dentistry | 23 | 11% |
| Neuroscience | 23 | 11% |
| Computer Science | 10 | 5% |
| Other | 30 | 15% |
| Unknown | 40 | 20% |