| Title |
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
|
|---|---|
| Published in |
PLOS ONE, April 2010
|
| DOI | 10.1371/journal.pone.0009979 |
| Pubmed ID | |
| Authors |
Patricia Spilman, Natalia Podlutskaya, Matthew J. Hart, Jayanta Debnath, Olivia Gorostiza, Dale Bredesen, Arlan Richardson, Randy Strong, Veronica Galvan |
| Abstract |
Reduced TOR signaling has been shown to significantly increase lifespan in a variety of organisms [1], [2], [3], [4]. It was recently demonstrated that long-term treatment with rapamycin, an inhibitor of the mTOR pathway[5], or ablation of the mTOR target p70S6K[6] extends lifespan in mice, possibly by delaying aging. Whether inhibition of the mTOR pathway would delay or prevent age-associated disease such as AD remained to be determined. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 11% |
| Venezuela, Bolivarian Republic of | 1 | 11% |
| Unknown | 7 | 78% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 89% |
| Scientists | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 593 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 1% |
| United States | 2 | <1% |
| Netherlands | 1 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| Ireland | 1 | <1% |
| India | 1 | <1% |
| Singapore | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Other | 5 | <1% |
| Unknown | 573 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 137 | 23% |
| Researcher | 103 | 17% |
| Student > Bachelor | 83 | 14% |
| Student > Master | 62 | 10% |
| Student > Doctoral Student | 25 | 4% |
| Other | 82 | 14% |
| Unknown | 101 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 163 | 27% |
| Biochemistry, Genetics and Molecular Biology | 103 | 17% |
| Neuroscience | 77 | 13% |
| Medicine and Dentistry | 53 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 23 | 4% |
| Other | 58 | 10% |
| Unknown | 116 | 20% |