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Clinical Utility of a Commercial LAM-ELISA Assay for TB Diagnosis in HIV-Infected Patients Using Urine and Sputum Samples

Overview of attention for article published in PLOS ONE, March 2010
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Title
Clinical Utility of a Commercial LAM-ELISA Assay for TB Diagnosis in HIV-Infected Patients Using Urine and Sputum Samples
Published in
PLOS ONE, March 2010
DOI 10.1371/journal.pone.0009848
Pubmed ID
Authors

Keertan Dheda, Virginia Davids, Laura Lenders, Teri Roberts, Richard Meldau, Daphne Ling, Laurence Brunet, Richard van Zyl Smit, Jonathan Peter, Clare Green, Motasim Badri, Leonardo Sechi, Surendra Sharma, Michael Hoelscher, Rodney Dawson, Andrew Whitelaw, Jonathan Blackburn, Madhukar Pai, Alimuddin Zumla

Abstract

The accurate diagnosis of TB in HIV-infected patients, particularly with advanced immunosuppression, is difficult. Recent studies indicate that a lipoarabinomannan (LAM) assay (Clearview-TB(R)-ELISA) may have some utility for the diagnosis of TB in HIV-infected patients; however, the precise subgroup that may benefit from this technology requires clarification. The utility of LAM in sputum samples has, hitherto, not been evaluated.

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Geographical breakdown

Country Count As %
South Africa 3 2%
Austria 1 <1%
India 1 <1%
United Kingdom 1 <1%
Denmark 1 <1%
United States 1 <1%
Unknown 192 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 43 22%
Student > Master 32 16%
Student > Ph. D. Student 31 16%
Student > Bachelor 19 10%
Student > Postgraduate 15 8%
Other 34 17%
Unknown 26 13%
Readers by discipline Count As %
Medicine and Dentistry 72 36%
Agricultural and Biological Sciences 32 16%
Biochemistry, Genetics and Molecular Biology 17 9%
Immunology and Microbiology 14 7%
Chemistry 9 5%
Other 25 13%
Unknown 31 16%