| Title |
Tetrahydrohyperforin and Octahydrohyperforin Are Two New Potent Inhibitors of Angiogenesis
|
|---|---|
| Published in |
PLOS ONE, March 2010
|
| DOI | 10.1371/journal.pone.0009558 |
| Pubmed ID | |
| Authors |
Beatriz Martínez-Poveda, Luisella Verotta, Ezio Bombardelli, Ana R. Quesada, Miguel Ángel Medina |
| Abstract |
We have previously shown that hyperforin, a phloroglucinol derivative found in St. John's wort, behaves as a potent anti-angiogenic compound. To identify the reactive group(s) mainly involved in this anti-angiogenic effect, we have investigated the anti-angiogenic properties of a series of stable derivatives obtained by oxidative modification of the natural product. In addition, in the present work we have studied the role of the four carbonyl groups present in hyperforin by investigating the potential of some other chemically stable derivatives. |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 4% |
| United States | 1 | 4% |
| Unknown | 25 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 19% |
| Researcher | 5 | 19% |
| Student > Bachelor | 4 | 15% |
| Student > Doctoral Student | 2 | 7% |
| Student > Ph. D. Student | 2 | 7% |
| Other | 4 | 15% |
| Unknown | 5 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 22% |
| Chemistry | 6 | 22% |
| Medicine and Dentistry | 4 | 15% |
| Biochemistry, Genetics and Molecular Biology | 3 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 11% |
| Other | 0 | 0% |
| Unknown | 5 | 19% |