| Title |
The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide
|
|---|---|
| Published in |
PLOS ONE, March 2010
|
| DOI | 10.1371/journal.pone.0009505 |
| Pubmed ID | |
| Authors |
Stephanie J. Soscia, James E. Kirby, Kevin J. Washicosky, Stephanie M. Tucker, Martin Ingelsson, Bradley Hyman, Mark A. Burton, Lee E. Goldstein, Scott Duong, Rudolph E. Tanzi, Robert D. Moir |
| Abstract |
The amyloid beta-protein (Abeta) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Abeta is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. However, Abeta has been shown to be a specific ligand for a number of different receptors and other molecules, transported by complex trafficking pathways, modulated in response to a variety of environmental stressors, and able to induce pro-inflammatory activities. |
X Demographics
The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 29% |
| United Kingdom | 2 | 6% |
| Canada | 1 | 3% |
| Australia | 1 | 3% |
| Unknown | 18 | 58% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 77% |
| Scientists | 5 | 16% |
| Practitioners (doctors, other healthcare professionals) | 2 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 17 | 2% |
| Germany | 6 | <1% |
| United Kingdom | 5 | <1% |
| Netherlands | 2 | <1% |
| Canada | 2 | <1% |
| Spain | 2 | <1% |
| France | 1 | <1% |
| Chile | 1 | <1% |
| India | 1 | <1% |
| Other | 10 | <1% |
| Unknown | 1072 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 202 | 18% |
| Researcher | 182 | 16% |
| Student > Bachelor | 158 | 14% |
| Student > Master | 126 | 11% |
| Student > Doctoral Student | 50 | 4% |
| Other | 194 | 17% |
| Unknown | 207 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 236 | 21% |
| Biochemistry, Genetics and Molecular Biology | 151 | 13% |
| Medicine and Dentistry | 131 | 12% |
| Neuroscience | 121 | 11% |
| Chemistry | 55 | 5% |
| Other | 181 | 16% |
| Unknown | 244 | 22% |