| Title |
Cytosine Methylation Dysregulation in Neonates Following Intrauterine Growth Restriction
|
|---|---|
| Published in |
PLOS ONE, January 2010
|
| DOI | 10.1371/journal.pone.0008887 |
| Pubmed ID | |
| Authors |
Francine Einstein, Reid F. Thompson, Tushar D. Bhagat, Melissa J. Fazzari, Amit Verma, Nir Barzilai, John M. Greally |
| Abstract |
Perturbations of the intrauterine environment can affect fetal development during critical periods of plasticity, and can increase susceptibility to a number of age-related diseases (e.g., type 2 diabetes mellitus; T2DM), manifesting as late as decades later. We hypothesized that this biological memory is mediated by permanent alterations of the epigenome in stem cell populations, and focused our studies specifically on DNA methylation in CD34+ hematopoietic stem and progenitor cells from cord blood from neonates with intrauterine growth restriction (IUGR) and control subjects. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Australia | 1 | <1% |
| United Kingdom | 1 | <1% |
| New Zealand | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 104 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 23% |
| Student > Ph. D. Student | 22 | 20% |
| Student > Master | 13 | 12% |
| Professor > Associate Professor | 11 | 10% |
| Student > Bachelor | 8 | 7% |
| Other | 20 | 18% |
| Unknown | 11 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 30% |
| Medicine and Dentistry | 26 | 24% |
| Biochemistry, Genetics and Molecular Biology | 17 | 15% |
| Nursing and Health Professions | 3 | 3% |
| Computer Science | 2 | 2% |
| Other | 16 | 15% |
| Unknown | 13 | 12% |