| Title |
Anandamide Suppresses Proliferation and Cytokine Release from Primary Human T-Lymphocytes Mainly via CB2 Receptors
|
|---|---|
| Published in |
PLOS ONE, January 2010
|
| DOI | 10.1371/journal.pone.0008688 |
| Pubmed ID | |
| Authors |
Maria Teresa Cencioni, Valerio Chiurchiù, Giuseppina Catanzaro, Giovanna Borsellino, Giorgio Bernardi, Luca Battistini, Mauro Maccarrone |
| Abstract |
Anandamide (AEA) is an endogenous lipid mediator that exerts several effects in the brain as well as in peripheral tissues. These effects are mediated mainly by two types of cannabinoid receptors, named CB(1)R and CB(2)R, making AEA a prominent member of the "endocannabinoid" family. Also immune cells express CB(1) and CB(2) receptors, and possess the whole machinery responsible for endocannabinoid metabolism. Not surprisingly, evidence has been accumulated showing manifold roles of endocannabinoids in the modulation of the immune system. However, details of such a modulation have not yet been disclosed in primary human T-cells. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 3 | 2% |
| United Kingdom | 1 | <1% |
| Italy | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 143 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 24 | 16% |
| Student > Ph. D. Student | 22 | 15% |
| Researcher | 18 | 12% |
| Student > Doctoral Student | 14 | 9% |
| Student > Master | 14 | 9% |
| Other | 27 | 18% |
| Unknown | 30 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 17% |
| Medicine and Dentistry | 23 | 15% |
| Biochemistry, Genetics and Molecular Biology | 22 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 10% |
| Neuroscience | 7 | 5% |
| Other | 21 | 14% |
| Unknown | 35 | 23% |