| Title |
Regulation of BMAL1 Protein Stability and Circadian Function by GSK3β-Mediated Phosphorylation
|
|---|---|
| Published in |
PLOS ONE, January 2010
|
| DOI | 10.1371/journal.pone.0008561 |
| Pubmed ID | |
| Authors |
Saurabh Sahar, Loredana Zocchi, Chisato Kinoshita, Emiliana Borrelli, Paolo Sassone-Corsi |
| Abstract |
Circadian rhythms govern a large array of physiological and metabolic functions. To achieve plasticity in circadian regulation, proteins constituting the molecular clock machinery undergo various post-translational modifications (PTMs), which influence their activity and intracellular localization. The core clock protein BMAL1 undergoes several PTMs. Here we report that the Akt-GSK3beta signaling pathway regulates BMAL1 protein stability and activity. |
Mendeley readers
The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Germany | 1 | <1% |
| Sweden | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Canada | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 187 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 25% |
| Researcher | 27 | 14% |
| Student > Master | 23 | 12% |
| Student > Bachelor | 20 | 10% |
| Professor > Associate Professor | 12 | 6% |
| Other | 30 | 15% |
| Unknown | 33 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 64 | 33% |
| Biochemistry, Genetics and Molecular Biology | 48 | 25% |
| Neuroscience | 14 | 7% |
| Medicine and Dentistry | 10 | 5% |
| Chemistry | 4 | 2% |
| Other | 17 | 9% |
| Unknown | 37 | 19% |