| Title |
Reprogramming of 3′ Untranslated Regions of mRNAs by Alternative Polyadenylation in Generation of Pluripotent Stem Cells from Different Cell Types
|
|---|---|
| Published in |
PLOS ONE, December 2009
|
| DOI | 10.1371/journal.pone.0008419 |
| Pubmed ID | |
| Authors |
Zhe Ji, Bin Tian |
| Abstract |
The 3' untranslated regions (3'UTRs) of mRNAs contain cis elements involved in post-transcriptional regulation of gene expression. Over half of all mammalian genes contain multiple polyadenylation sites that lead to different 3'UTRs for a gene. Studies have shown that the alternative polyadenylation (APA) pattern varies across tissues, and is dynamically regulated in proliferating or differentiating cells. Generation of induced pluripotent stem (iPS) cells, in which differentiated cells are reprogrammed to an embryonic stem (ES) cell-like state, has been intensively studied in recent years. However, it is not known how 3'UTRs are regulated during cell reprogramming. |
Mendeley readers
The data shown below were compiled from readership statistics for 261 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 5% |
| Germany | 2 | <1% |
| Italy | 2 | <1% |
| China | 2 | <1% |
| Brazil | 1 | <1% |
| Sweden | 1 | <1% |
| United Kingdom | 1 | <1% |
| Chile | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Other | 3 | 1% |
| Unknown | 235 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 90 | 34% |
| Researcher | 60 | 23% |
| Student > Master | 23 | 9% |
| Student > Doctoral Student | 15 | 6% |
| Professor > Associate Professor | 14 | 5% |
| Other | 33 | 13% |
| Unknown | 26 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 136 | 52% |
| Biochemistry, Genetics and Molecular Biology | 67 | 26% |
| Medicine and Dentistry | 14 | 5% |
| Neuroscience | 5 | 2% |
| Engineering | 3 | 1% |
| Other | 9 | 3% |
| Unknown | 27 | 10% |