| Title |
The Association of Virulence Factors with Genomic Islands
|
|---|---|
| Published in |
PLOS ONE, December 2009
|
| DOI | 10.1371/journal.pone.0008094 |
| Pubmed ID | |
| Authors |
Shannan J. Ho Sui, Amber Fedynak, William W. L. Hsiao, Morgan G. I. Langille, Fiona S. L. Brinkman |
| Abstract |
It has been noted that many bacterial virulence factor genes are located within genomic islands (GIs; clusters of genes in a prokaryotic genome of probable horizontal origin). However, such studies have been limited to single genera or isolated observations. We have performed the first large-scale analysis of multiple diverse pathogens to examine this association. We additionally identified genes found predominantly in pathogens, but not non-pathogens, across multiple genera using 631 complete bacterial genomes, and we identified common trends in virulence for genes in GIs. Furthermore, we examined the relationship between GIs and clustered regularly interspaced palindromic repeats (CRISPRs) proposed to confer resistance to phage. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| United Kingdom | 1 | 25% |
| Canada | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 233 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| United Kingdom | 3 | 1% |
| Chile | 2 | <1% |
| India | 2 | <1% |
| Spain | 2 | <1% |
| Brazil | 1 | <1% |
| France | 1 | <1% |
| Canada | 1 | <1% |
| Argentina | 1 | <1% |
| Other | 6 | 3% |
| Unknown | 209 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 54 | 23% |
| Student > Ph. D. Student | 50 | 21% |
| Student > Master | 25 | 11% |
| Student > Bachelor | 20 | 9% |
| Student > Postgraduate | 11 | 5% |
| Other | 45 | 19% |
| Unknown | 28 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 119 | 51% |
| Biochemistry, Genetics and Molecular Biology | 40 | 17% |
| Immunology and Microbiology | 14 | 6% |
| Computer Science | 12 | 5% |
| Medicine and Dentistry | 4 | 2% |
| Other | 12 | 5% |
| Unknown | 32 | 14% |