| Title |
Protective Role of R-spondin1, an Intestinal Stem Cell Growth Factor, against Radiation-Induced Gastrointestinal Syndrome in Mice
|
|---|---|
| Published in |
PLOS ONE, November 2009
|
| DOI | 10.1371/journal.pone.0008014 |
| Pubmed ID | |
| Authors |
Payel Bhanja, Subhrajit Saha, Rafi Kabarriti, Laibin Liu, Namita Roy-Chowdhury, Jayanta Roy-Chowdhury, Rani S. Sellers, Alan A. Alfieri, Chandan Guha |
| Abstract |
Radiation-induced gastrointestinal syndrome (RIGS) results from a combination of direct cytocidal effects on intestinal crypt and endothelial cells and subsequent loss of the mucosal barrier, resulting in electrolyte imbalance, diarrhea, weight loss, infection and mortality. Because R-spondin1 (Rspo1) acts as a mitogenic factor for intestinal stem cells, we hypothesized that systemic administration of Rspo1 would amplify the intestinal crypt cells and accelerate the regeneration of the irradiated intestine, thereby, ameliorating RIGS. |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| United Kingdom | 1 | 1% |
| Unknown | 76 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 30% |
| Student > Ph. D. Student | 18 | 23% |
| Other | 6 | 8% |
| Professor > Associate Professor | 4 | 5% |
| Student > Master | 4 | 5% |
| Other | 8 | 10% |
| Unknown | 15 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 35% |
| Biochemistry, Genetics and Molecular Biology | 12 | 15% |
| Medicine and Dentistry | 11 | 14% |
| Immunology and Microbiology | 4 | 5% |
| Environmental Science | 1 | 1% |
| Other | 6 | 8% |
| Unknown | 17 | 22% |