Title |
A Predictive Phosphorylation Signature of Lung Cancer
|
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Published in |
PLOS ONE, November 2009
|
DOI | 10.1371/journal.pone.0007994 |
Pubmed ID | |
Authors |
Chang-Jiun Wu, Tianxi Cai, Klarisa Rikova, David Merberg, Simon Kasif, Martin Steffen |
Abstract |
Aberrant activation of signaling pathways drives many of the fundamental biological processes that accompany tumor initiation and progression. Inappropriate phosphorylation of intermediates in these signaling pathways are a frequently observed molecular lesion that accompanies the undesirable activation or repression of pro- and anti-oncogenic pathways. Therefore, methods which directly query signaling pathway activation via phosphorylation assays in individual cancer biopsies are expected to provide important insights into the molecular "logic" that distinguishes cancer and normal tissue on one hand, and enables personalized intervention strategies on the other. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 25% |
Student > Master | 8 | 16% |
Student > Ph. D. Student | 7 | 14% |
Student > Bachelor | 5 | 10% |
Professor | 4 | 8% |
Other | 9 | 18% |
Unknown | 5 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 39% |
Biochemistry, Genetics and Molecular Biology | 12 | 24% |
Computer Science | 5 | 10% |
Medicine and Dentistry | 4 | 8% |
Chemistry | 2 | 4% |
Other | 2 | 4% |
Unknown | 6 | 12% |