| Title |
Periconceptional Maternal Folic Acid Use of 400 µg per Day Is Related to Increased Methylation of the IGF2 Gene in the Very Young Child
|
|---|---|
| Published in |
PLOS ONE, November 2009
|
| DOI | 10.1371/journal.pone.0007845 |
| Pubmed ID | |
| Authors |
Régine P. Steegers-Theunissen, Sylvia A. Obermann-Borst, Dennis Kremer, Jan Lindemans, Cissy Siebel, Eric A. Steegers, P. Eline Slagboom, Bastiaan T. Heijmans |
| Abstract |
Countries worldwide recommend women planning pregnancy to use daily 400 microg of synthetic folic acid in the periconceptional period to prevent birth defects in children. The underlying mechanisms of this preventive effect are not clear, however, epigenetic modulation of growth processes by folic acid is hypothesized. Here, we investigated whether periconceptional maternal folic acid use and markers of global DNA methylation potential (S-adenosylmethionine and S-adenosylhomocysteine blood levels) in mothers and children affect methylation of the insulin-like growth factor 2 gene differentially methylation region (IGF2 DMR) in the child. Moreover, we tested whether the methylation of the IGF2 DMR was independently associated with birth weight. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 290 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| France | 1 | <1% |
| India | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Czechia | 1 | <1% |
| China | 1 | <1% |
| New Zealand | 1 | <1% |
| Unknown | 281 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 56 | 19% |
| Student > Bachelor | 51 | 18% |
| Student > Master | 49 | 17% |
| Researcher | 33 | 11% |
| Student > Doctoral Student | 16 | 6% |
| Other | 51 | 18% |
| Unknown | 34 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 71 | 24% |
| Medicine and Dentistry | 62 | 21% |
| Biochemistry, Genetics and Molecular Biology | 53 | 18% |
| Nursing and Health Professions | 18 | 6% |
| Psychology | 7 | 2% |
| Other | 30 | 10% |
| Unknown | 49 | 17% |