| Title |
Fyn Mediates Leptin Actions in the Thymus of Rodents
|
|---|---|
| Published in |
PLOS ONE, November 2009
|
| DOI | 10.1371/journal.pone.0007707 |
| Pubmed ID | |
| Authors |
Alessandra Girasol, Gabriela G. Albuquerque, Eli Mansour, Eliana P. Araújo, Giovanna Degasperi, Raphael G. Denis, José B. Carvalheira, Mário J. Saad, Lício A. Velloso |
| Abstract |
Several effects of leptin in the immune system rely on its capacity to modulate cytokine expression and apoptosis in the thymus. Surprisingly, some of these effects are dependent on signal transduction through the IRS1/PI3-kinase, but not on the activation of JAK2. Since all the well known effects of leptin in different cell types and tissues seem to be dependent on JAK2 activation, we hypothesized that, at least for the control of thymic function, another, unknown kinase could mediate the transduction of the leptin signal from the ObR towards the IRS1/PI3-kinase signaling cascade. |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 6 | 23% |
| Researcher | 6 | 23% |
| Student > Ph. D. Student | 5 | 19% |
| Student > Bachelor | 2 | 8% |
| Other | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 5 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 46% |
| Medicine and Dentistry | 4 | 15% |
| Neuroscience | 2 | 8% |
| Immunology and Microbiology | 1 | 4% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 5 | 19% |