| Title |
Twist: A Regulator of Epithelial-Mesenchymal Transition in Lung Fibrosis
|
|---|---|
| Published in |
PLOS ONE, October 2009
|
| DOI | 10.1371/journal.pone.0007559 |
| Pubmed ID | |
| Authors |
Veronika Pozharskaya, Edilson Torres-González, Mauricio Rojas, Anthony Gal, Minal Amin, Sheila Dollard, Jesse Roman, Arlene A. Stecenko, Ana L. Mora |
| Abstract |
Several studies have implicated viral infection as an important factor in the pathogenesis of IPF and related fibrotic lung disorders. Viruses are thought to cause epithelial cell injury and promote epithelial-mesenchymal transition (EMT), a process whereby differentiated epithelial cells undergo transition to a mesenchymal phenotype, and considered a source of fibroblasts in the setting of lung injury. We have demonstrated an association between the epithelial injury caused by chronic herpes virus infection with the murine gamma-herpes virus, MHV68, and lung fibrosis. We hypothesize that EMT in this model of virus-induced pulmonary fibrosis is driven by the expression of the transcription factor Twist. |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Denmark | 1 | 1% |
| Germany | 1 | 1% |
| Norway | 1 | 1% |
| Unknown | 83 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 22% |
| Researcher | 15 | 17% |
| Student > Master | 10 | 11% |
| Student > Bachelor | 8 | 9% |
| Student > Doctoral Student | 7 | 8% |
| Other | 15 | 17% |
| Unknown | 13 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 36% |
| Medicine and Dentistry | 22 | 25% |
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Immunology and Microbiology | 2 | 2% |
| Environmental Science | 1 | 1% |
| Other | 4 | 5% |
| Unknown | 16 | 18% |